Protein Details: Neuronal acetylcholine receptor subunit alpha-6

Protein ID

ICDB_Pro_0527

Protein Name

Neuronal acetylcholine receptor subunit alpha-6

Gene Name

Chrna6; Acra6

Organism

Rattus norvegicus (Rat)

Length

493 amino acids

AlphaFoldDB

AF-P43143-F1-model_v4.pdb

Function

After binding acetylcholine; the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. .

Sequence

MLNGWGRGDLRSGLCLWICGFLAFFKGSRGCVSEEQLFHTLFAHYNRFIRPVENVSDPVTVHFELAITQLANVDEVNQIMETNLWLRHVWKDYRLCWDPTEYDGIETLRVPADNIWKPDIVLYNNAVGDFQVEGKTKALLKYDGVITWTPPAIFKSSCPMDITFFPFDHQNCSLKFGSWTYDKAEIDLLIIGSKVDMNDFWENSEWEIVDASGYKHDIKYNCCEEIYTDITYSFYIRRLPMFYTINLIIPCLFISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLVGEYLLFTMIFVTLSIVVTVFVLNIHYRTPATHTMPKWVKTMFLQVFPSILMMRRPLDKTKEMDGVKDPKTHTKRPAKVKFTHRKEPKLLKECRHCHKSSEIAPGKRLSQQPAQWVTENSEHPPDVEDVIDSVQFIAENMKSHNETKEVEDDWKYMAMVVDRVFLWVFIIVCVFGTVGLFLQPLLGNTGAS

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1016/0304-3940(90)90287-j; 10.1016/0014-4886(91)90004-v; 10.1007/bf02736842; 10.1016/s0014-5793(96)01383-x; 10.1007/s004390050885; 10.1007/pl00010921; 10.1038/nature04601; 10.1101/gr.2596504; 10.1021/bi048918g; 10.1124/mol.105.017459; 10.1038/452537a; 10.1038/nature06885; 10.1038/nature06846; 10.1038/ng.109; 10.1016/j.bcp.2015.08.084; 10.1111/jnc.13718; 10.1016/j.ajhg.2019.10.004

RefSeq

NP_000734.2 [P32297-2]; NP_001160166.1 [P32297-3]